PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma

Many congratulations to Imran (Aslam) for his publication, PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma, today in the Proceedings of the National Academy of Sciences of the USA. This study was a collaboration of the Tyner, Druker and Keller laboratories - highlighting some key growth factor receptor targets in this disease. This study was funded…
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Patient-derived xenografts for individualized care in advanced sarcoma

Patient-derived xenografts for individualized care in advanced sarcoma (Article first published online 4 April 2014) AUTHORS: Justin Stebbing MA, FRCP, FRCPath, PhD, Keren Paz PhD, Gary K. Schwartz MD, Leonard H. Wexler MD, Robert Maki MD, PhD, Raphael E. Pollock MD, PhD, Ronnie Morris MD, Richard Cohen MD, Arjun Shankar MD, Glen Blackman MBBS, Victoria…
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Double-pronged attack could treat common children’s cancer

Shipley - Double-Pronged Attack Double-pronged attack could treat common children's cancer Date: November 1, 2013 Source: Institute of Cancer Research A dual-pronged strategy using two experimental cancer drugs together could successfully treat a childhood cancer by inhibiting tumour growth and blocking off the escape routes it uses to become resistant to treatment, finds a new…
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NCI Webinar on Children’s Cancer and Pediatric Cancer Advocacy Now Online

The NCI held its 64th Meeting of the Director’s Consumer Liaison Group (DCLG) on Friday, February 21, 2014. For those who did not attend, either in person or via the webcast, or want to see it again, you can visit the NIH website and watch the entire 5 hour 45 minute program. This link will…
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Flexibility Could Be Important

This month's issue of Nature Reviews|Cancer (March 2014) hightlights an advancement in the understanding of alveolar rhabdomyosarcoma. Drs. Charles Keller,Ken Kikuchi and colleagues "generated an aRMS knockin mouse model that expresses the common fusion gene paired box 3 (Pax3)-forkhead box O1A (Foxo1a) under the regulation of the normal Pax3 promoter. The authors also expressed an…
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Technique allows for radiation-free detection of tumors, study finds

From the Stanford School of Medicine, by Erin Digitale and posted on ACOR by Mimi Olsson Researchers at the Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford have developed a way to scan young cancer patients’ bodies for tumors without exposing them to radiation. The technique could reduce patients’ risk of developing…
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Genetic Mutations Identified in Rhabdomyosarcoma Tumors

From Healio - HemOncToday Genetic mutations identified in rhabdomyosarcoma tumors Shern JF. Cancer ;4:216-231. February 14, 2014 Newly discovered recurrent mutations in the genes FBXW7 and BCOR in rhabdomyosarcoma may offer new therapeutic options and improve outcomes for this type of pediatric cancer, according to results of a study conducted by NCI. Researchers also found…
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NCI Meeting on Pediatric Cancer Drug Development

Jenny Cartwright shared this message from the Children's Cause Cancer Advocacy Group Special Announcement: The National Cancer Institute will hold a meeting about pediatric cancer drug development Friday, Feb. 21 Dear Childhood Cancer Advocate, There will be a meeting next week at the National Cancer Institute (NCI) dedicated to pediatric cancer drug development. The NCI…
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Nanobiotix outlines development plan for NBTXR3 in soft tissue sarcoma

Nanobiotix (Euronext: NANO), a French nanomedicine company focused on cancer therapy, has announced today its development plan for the CE marking of NBTXR3, the first product from the NanoXray pipeline. The positive results from the pilot phase of NBTXR3 in patients with advanced soft tissue sarcoma (STS), allow Nanobiotix to finalize and to announce its…
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Rare Disease Day – Feb 28, 2014

February 28th has been designated as Rare Disease Day, a day where patient organizations around the world unite to promote awareness of the challenges, hopes and needs of those living with rare diseases. For 2014, the focus is on caregiving, and the global theme is “Join Together for Better Care.” As an advocacy organization supporting…
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