Flexibility Could Be Important

This month's issue of Nature Reviews|Cancer (March 2014) hightlights an advancement in the understanding of alveolar rhabdomyosarcoma. Drs. Charles Keller,Ken Kikuchi and colleagues "generated an aRMS knockin mouse model that expresses the common fusion gene paired box 3 (Pax3)-forkhead box O1A (Foxo1a) under the regulation of the normal Pax3 promoter. The authors also expressed an…
Continue Reading »

Technique allows for radiation-free detection of tumors, study finds

From the Stanford School of Medicine, by Erin Digitale and posted on ACOR by Mimi Olsson Researchers at the Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford have developed a way to scan young cancer patients’ bodies for tumors without exposing them to radiation. The technique could reduce patients’ risk of developing…
Continue Reading »

Genetic Mutations Identified in Rhabdomyosarcoma Tumors

From Healio - HemOncToday Genetic mutations identified in rhabdomyosarcoma tumors Shern JF. Cancer ;4:216-231. February 14, 2014 Newly discovered recurrent mutations in the genes FBXW7 and BCOR in rhabdomyosarcoma may offer new therapeutic options and improve outcomes for this type of pediatric cancer, according to results of a study conducted by NCI. Researchers also found…
Continue Reading »

NCI Meeting on Pediatric Cancer Drug Development

Jenny Cartwright shared this message from the Children's Cause Cancer Advocacy Group Special Announcement: The National Cancer Institute will hold a meeting about pediatric cancer drug development Friday, Feb. 21 Dear Childhood Cancer Advocate, There will be a meeting next week at the National Cancer Institute (NCI) dedicated to pediatric cancer drug development. The NCI…
Continue Reading »

Nanobiotix outlines development plan for NBTXR3 in soft tissue sarcoma

Nanobiotix (Euronext: NANO), a French nanomedicine company focused on cancer therapy, has announced today its development plan for the CE marking of NBTXR3, the first product from the NanoXray pipeline. The positive results from the pilot phase of NBTXR3 in patients with advanced soft tissue sarcoma (STS), allow Nanobiotix to finalize and to announce its…
Continue Reading »

Rare Disease Day – Feb 28, 2014

February 28th has been designated as Rare Disease Day, a day where patient organizations around the world unite to promote awareness of the challenges, hopes and needs of those living with rare diseases. For 2014, the focus is on caregiving, and the global theme is “Join Together for Better Care.” As an advocacy organization supporting…
Continue Reading »

National Academies Book On Clinical Trial Data Sharing

2/4/14 National Academies Book On Clinical Trial Data Sharing The National Academies Press just published a book on sharing clinical trial data - a topic of interest to each of us in the Rhabdo community. The book is available for purchase as a paperback for $ or as a free download in pdf format. You…
Continue Reading »

NIH scientists map genetic changes that drive tumors in a common pediatric soft-tissue cancer

A Press Release from the NIH - Effort led by Javed Khan, Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments…
Continue Reading »

Save the Date: Rhabdomyosarcoma & Soft Tissue Sarcoma Conference

The Pablove Foundation is hosting a scientific conference on rhabdomyosarcoma & soft tissue sarcoma November 6-8, 2014 in Los Angeles. This is a by-invitation meeting for clinician-scientists and researchers from the US and abroad; however, the symposium on Saturday November 8 will be open to the public. Registration information will likely be available late Summer/early…
Continue Reading »

A much anticipated sequencing paper on Rhabdomyosarcoma

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors. Authors: Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole…
Continue Reading »
Skip to toolbar