Tumor Cells in a Hurry: Duct Tape will do!

A New Paper by Kickuchi, Keller and Colleagues on a completely new way of thinking about what Pax3:Foxo1a does. The paper is titled: Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma. In alveolar rhabdomyosarcoma, 70-75% of tumors carry the Pax3:Foxo1a oncogene. This oncogene seems to account for a large difference…
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FDA Public Workshops on Rare Childhood Diseases

Jennifer Inman-Cartwright emailed me today saying that she sat in on a conference call with the Children's Cancer Caucus - Advocacy (CCCA) where the topic was the FDA and orphan drug issues. She forward the slide presentations which you can view and download. The first presentation was by James E. Valentine, MHS, JD Candidate at…
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CytRx Reports Highly Statistically Significant Positive Results from its Global Phase 2b Clinical Trial

CytRx, a biopharmaceutical research and development company specializing in oncology, today announced highly positive top-line efficacy results from a multicenter, randomized, open-label global Phase 2b clinical trial. The trial investigated the efficacy and safety of aldoxorubicin compared with doxorubicin in subjects with first-line metastatic, locally advanced or unresectable soft tissue sarcomas (STS). Aldoxorubicin combines the…
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Gene Sequencing Project Finds Family of Drugs with Promise for Treating Childhood Tumor

(MEMPHIS, Tenn. – December 9, 2013) Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue. The findings are the latest from the St. Jude Children's Research Hospital–Washington University…
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Important: Request from NIH/NCI for Public Input on Availability of Clinical Trial Results

Purpose With this Notice, the National Cancer Institute (NCI) announces and seeks public input on NCI’s plan to promote and ensure public availability of results from all commenced, NCI-supported clinical trials. Background NCI, a component of the National Institutes of Health (NIH), is dedicated to improving the health of Americans by conducting and funding biomedical…
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Tips for Interpreting Scientific Claims

Here's the link to an article that talks about ways to help non-scientists interrograte advisers and to grasp the limitations of evidence.  Published in the Nov 20, 2013 issue of Nature, the article suggests 20 concepts that should be part of the education of anyone who may have to interact with science or scientists.  Although…
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