Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition See Original Here Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the malignant progression of RMS, especially…
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Does routine imaging of patients for progression or relapse improve survival in rhabdomyosarcoma?

Does routine imaging of patients for progression or relapse improve survival in rhabdomyosarcoma? Jody L. Lin MD, R. Paul Guillerman MD, Heidi V. Russell MD, Philip J. Lupo PhD, MPH, Lauren Nicholls MD andM. Fatih Okcu MD, MPH,* Article first published online: 16 SEP 2015 | See Original Here DOI: Background Patients with rhabdomyosarcoma (RMS)…
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Hearing loss in survivors of childhood head and neck rhabdomyosarcoma; a long-term follow-up study

Hearing loss in survivors of childhood head and neck rhabdomyosarcoma; a long-term follow-up study Reineke A. Schoot, Eleonoor Theunissen, Olga Slater3, Marta Lopez-Yurda, Charlotte L. Zuur, Mark N. Gaze, Yen-Ch'ing Chang, Henry C. Mandeville, Jennifer E. Gains, Kaukab Rajput, Bradley R. Pieters, Raquel Davila Fajardo, Rishi Talwar, Huib N. Caron, Alfons Balm, Wouter A. Dreschler…
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SKP2 supports cell proliferation and is regulated by Notch signaling in myoblasts and embryonal rhabdomyosarcoma

SKP2 supports cell proliferation and is regulated by Notch signaling in myoblasts and embryonal rhabdomyosarcoma Rossella Rota, Laura Adesso, Beatrice Conti, Roberta Ciarapica, Lavinia De Raimondi, Maria Salvo, Sonia Rodriguez, Nadia Carlesso, Lucio Miele, and Franco Locatelli Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here Abstract Background: Rhabdomyosarcoma (RMS)…
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Myogenic regulatory factors and their role in embryonal rhabdomyosarcoma

Myogenic regulatory factors and their role in embryonal rhabdomyosarcoma Ines M. Tenente, Myron Ignatius, Eleanor Chen, Madeline Hayes, and David M. Langenau Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here Abstract Rhabdomyosarcoma (RMS) is a pediatric sarcoma of muscle. RAS pathway activation is the dominant oncogenic driver event in…
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FGFR4 as a potential therapeutic target for monoclonal antibody based intervention in rhabdomyosarcoma

FGFR4 as a potential therapeutic target for monoclonal antibody based intervention in rhabdomyosarcoma Sivasubramanian Baskar, Nityashree Shivaprasad, Zhongyu Zhu, Dimiter Dimitrov, Mhairi Sigrist, Poul Sorensen, Marielle Yohe, John Shern, John Maris, Crystal Mackall, and Javed Khan Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here Abstract Background: Rhabdomyosarcoma (RMS) is…
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Notch signaling increases the number of relapse-driving tumor propagating cells in embryonal rhabdomyosarcoma

Notch signaling increases the number of relapse-driving tumor propagating cells in embryonal rhabdomyosarcoma Myron Ignatius, Riadh Lobbardi, Madeline Hayes, Eleanor Chen, Karin McCarthy, G. Petur Nielsen, Brian Beleyea, Corinne Linardic, Javed Khan, Charles Keller, and David M. Langenau Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here" Abstract Embryonal rhabdomyosarcoma…
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Furin activity: A driver of rhabdomyosarcoma progression

Furin activity: A driver of rhabdomyosarcoma progression Patricia AIM Jaaks, Gianmarco Meier, Beat W. Schäfer, and Michele Bernasconi Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The prognosis and survival rate is often very poor and therefore…
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PAX3-FOXO1 is essential for initiation but not for recurrence during rhabdomyosarcoma tumorigenesis

PAX3-FOXO1 is essential for initiation but not for recurrence during rhabdomyosarcoma tumorigenesis Puspa R. Pandey, Stephen M. Hewitt, Markku M. Miettinen, and Frederic G. Barr Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA See Original Here Abstract The PAX3-FOXO1 fusion gene, which is generated by a 2; 13 chromosomal translocation, is a…
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The role of childhood immunizations and infections on the risk of pediatric rhabdomyosarcoma

The role of childhood immunizations and infections on the risk of pediatric rhabdomyosarcoma Hari Sankaran, Heather Danysh, Michael E. Scheurer, M. Fatih Okcu, and Philip J. Lupo Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Abstract
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