Loss of MEF2D Expression Inhibits Differentiation and Contributes to Oncogenesis in Rhabdomyosarcoma Cells

From Molecular Cancer: Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the most common form of soft tissue tumors in children. RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the defects present in these cells that block myogenesis. Methods: Protein and RNA analysis…
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Rb1 Loss Modifies but does not Initiate Alveolar Rhabdomyosarcoma

This article, published in Skeletal Muscle Journal by lead authors Ken Kikuchi , Eri Taniguchi and colleagues,  investigates the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. From the article's abstract: Results Rb1 loss was not a necessary and sufficient mutational event for rhabdomyosarcomagenesis, nor a strong cooperative initiating mutation. Instead,…
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