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A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance for Research Through Collaboration study
AS Pappo, G Vassal, JJ Crowley, V Bolejack… - Cancer, 2014
BACKGROUND Insulin-like growth factor-1 receptor (IGF-1R) is implicated in the
pathogenesis of rhabdomyosarcoma (RMS), osteosarcoma (OS), and synovial sarcoma
(SS). The authors conducted a multi-institutional phase 2 trial of the monoclonal antibody ...

Insulin-like growth factor 1 receptor inhibitors: Where do we come from? What are we? Where are we going?
Insulin‐like growth factor 1 receptor inhibitors: Where do we come from? What are we? Where are we going?
B Chmielowski - Cancer, 2014
... In this issue of Cancer, Pappo et al present results from a phase 2 trial of the IGF-1R blocking
antibody R1507 in patients with rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other
soft tissue sarcomas.[8] In the category of sarcoma clinical trials, it was a large study ...

The hunt for a PAX3-FOXO1 motif (939.4)
K Johanson, C Collins, D Stewart, T Cherlin - The FASEB Journal, 2014
... Abstract. Alveolar Rhabdomyosarcoma (ARMS) patients carrying a chromosomal translocation
of PAX3 and FOXO1 have the highest mortality rates, indicating the importance of
understanding how this transcription factor influences gene expression. ...

Parent Stress in Childhood Cancer
MAK Basher, MR Karim, N Sultana, KJ Hossain… - Bangladesh Medical …, 2014
... that 61.4%(n=243) of the children had been suffering form leukemia, 17.4%(n=69) lymphoma,
8.3%(n=33) reticuloblastoma, 2.5%(n=10) neuroblastoma, 1.1%(n=4) solid tumors and
9.3%(n=48) were from other cancers such as embryoma, rhabdomyosarcoma, testicular tumors ...

Incorporation of Ophiobolin A into Novel Chemoembolization Particles for Cancer Cell Treatment
R Morrison, C Gardiner, A Evidente, R Kiss, H Townley - Pharmaceutical Research, 2014
... location. To investigate cell death mechanism of OphA on a Rhabdomyosarcoma
cancer (RD) cell line. Rhabdomyosarcoma is the most common soft tissue sarcoma
in children; with a 5-year survival rate of between 30 and 65%. ...