Recent Papers on Rhabdomyosarcoma – 10 August 2014
From Google Scholar Alerts
Please note that some are abstracts requiring subscriptions or purchase of the full article, others provide a more comprehensive view of the paper.
Misdiagnosed Rhabdomyosarcoma of the Vulva.
YS Kim, HS Han, JH Sang - Soonchunhyang Medical Science, 2014
Abstract Vulvar carcinoma is a rare disease that accounts for 5% of gynecologic cancers.
Sarcomas of the vulva are extremely rare, and account for only 1% to 3% of all vulvar
malignancies. We report of a case of a 26 years woman with a vulva mass. Excision was ...
Pathology and Diagnosis of SMARCB1-deficient Tumors
AS Margol, AR Judkins - Cancer Genetics, 2014
Malignant rhabdoid tumors can occur in the kidney, central nervous system as well as extracranial/extrarenal locations and are characterized by alterations in the SMARCB1 gene. They occur in infants and young children and confer a poor prognosis requiring aggressive therapeutic interventions to improve the chances for survival. MRT pose a diagnostic challenge as they display heterogeneous histopathological features and differentiate along multiple lineages.
Clinical research on the treatment effects of radioactive 125I seeds interstitial brachytherapy on children with primary orbital rhabdomyosarcoma
X Ge, J Ma, H Dai, L Ren, Q Li, J Shi - Medical Oncology, 2014
Abstract Rhabdomyosarcoma (RMS) is one of the most common primary orbital malignancies. However, orbital RMS is a very rare disease, especially in childhood, and the tumor has a high degree of malignancy and rapid development. The objective of the ...
Rhabdomyosarcoma thigh in a 45-year-old male: A rare presentation
A Saha, C Roy, R Sarkar, P Kayal - Clinical Cancer Investigation Journal, 2014
Abstract Rhabdomyosarcoma (RMS) is a common childhood cancer, constituting more than
50% of all soft tissue sarcoma, but it is an uncommon neoplasm in adult. We reported a case of 45-year-old male patient presented with a huge swelling in his left thigh. Magnetic ...
Overview of the rhabdomyosarcoma: from a molecular study to a therapeutic design
S Lara Cerrillo, E Itarte - 2014
Overview of the Rhabdomyosarcoma: from a molecular ... Lara Cerrillo, Sandra Bachelor of
Biotechnology, Universitat Autònoma de Barcelona (UAB). 08193 Bellaterra, Spain. ... Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children aged 0-14 years old, ...
Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre: Reassessment in the Era of Ancillary Molecular Diagnosis
K Thway, J Wang, T Mubako, C Fisher - Sarcoma, 2014
... These were 7 tests for h-caldesmon (for leiomyosarcoma), 3 CDK4 (for WDL/DDL), 2 DOG1
(for GIST), 2 beta-catenin (for fibromatosis), 1 each of CD34 (DFSP), desmin, myogenin
(rhabdomyosarcoma (RMS)), p63 (sarcomatoid carcinoma), PSAP (prostatic carcinoma), and ...
The Hippo signal transduction network in skeletal and cardiac muscle
H Wackerhage, DP Del Re, RN Judson, M Sudol… - Science Signaling, 2014
The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads.
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
H King, T Aleksic, P Haluska, VM Macaulay - Cancer Treatment Reviews, 2014
IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity of IGF-1R targeting, and recognition that low IGF bioactivity prot.
A Case of Lung Carcinoma with Rhabdoid Phenotype Mimicking an Aspergilloma in Patient with Recurrent Hemoptysis
MW Kim, SJ Rew, SJ Eun, US Lee, C Woo, MD Park… - 2014
... in 1978, in a pediatric population1. The term 'rhabdoid' in rhabdoid tumor refers
to rhabdomyosarcoma because of the morphological similarity of the cells in these
two types of tumors4. While most renal rhabdoid tumors are ...
Upper Extremity Considerations for Oncologic Surgery
JC Wong, JA Abraham - Orthopedic Clinics of North America, 2014
According to the National Cancer Institute estimates, more than 3000 people would be diagnosed with primary bone or joint malignancy and more than 11,000 people would be diagnosed with a soft tissue sarcoma in 2013.1 A large report on more than 1000 soft tissue sarcomas treated at Memorial Sloan Kettering Cancer Center showed that the upper extremity was involved in approximately 29% of cases.2 Although primary bone and soft tissue tumors of the upper extremity are infrequent, it is imperative that the clinician be familiar with a systematic approach to the diagnosis and treatment of these conditions to prevent inadvertently compromising patient outcome.