Recent Papers on Rhabdomyosarcoma – 25 Nov 2014
From Google Scholar Alerts
Please note that some are abstracts requiring subscriptions or purchase of the full article, others provide a more comprehensive view of the paper.
Delayed Primary Excision with Subsequent Modification of Radiotherapy Dose for Intermediate Risk Rhabdomyosarcoma (RMS): A Report from the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee
DA Rodeberg, MD Wharam, ER Lyden, JA Stoner… - International Journal of …, 2014
Abstract The majority of intermediate risk Rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the ...
Soft Tissue Sarcomas
DM Parham, SC Kaste, A Raju, MB McCarville - Pediatric Malignancies: Pathology …, 2015
... 2006;48:3–12. Parham D, Pao W, Pratt C, et al. A histological grading system of prognostic significance for childhood – adolescent soft tissue sarcomas other than rhabdomyosarcoma. Mod Pathol. ... Are myogenin and myoD1 expression specific for rhabdomyosarcoma? ...
Pediatric Cancer in the Head and Neck
Z Yu, DM Parham, MK Kukreja - Pediatric Malignancies: Pathology and Imaging, 2015
... Pediatric ear tumors include paraganglioma and rhabdomyosarcoma, the latter being also common in other head and neck locations such as nasal cavity. ... 2011;81(4):15. Ahmed AA, Tsokos M. Sinonasal rhabdomyosarcoma in children and young adults. Int J Surg Pathol. ...
Primary Desmoplastic Small Round Cell Tumor of Upper Cervical Lymph Nodes
F Faras, F Abo-Alhassan, AH Hussain, NJ Sebire… - Oral Surgery, Oral Medicine, …, 2014
... Ewing sarcoma and rhabdomyosarcoma have distinct histopathology and immunohistochemical staining patterns, which were lacking in our case. The differential diagnoses of small round cell tumors are summarized in Table 2. ... Rhabdomyosarcoma, 1. strap tadpole cells. 2. ...
AB Warrick, K Gritsenko, M Aquino - Essentials of Pharmacology for Anesthesia, Pain …, 2015
... g e therapy if necessary Soft tissue and bone cancers Soft tissue sarcomas (ie, rhabdomyosarcoma) T reatment is often surgical excision if possible. Ewing's sarcoma class of tumors often receiv es ... y and/or radiation therap y Rhabdomyosarcoma V incristine + ...
Seven Strains of Enterovirus D68 Detected in the United States during the 2014 Severe Respiratory Disease Outbreak
BA Brown, WA Nix, M Sheth, M Frace, MS Oberste - Genome Announcements, 2014
... One complete and six near-complete EV-D68 genome sequences were generated from RNA extracted directly from nasopharyngeal (NP) swab supernatants or from virus isolates obtained by inoculation of NP supernatants into human rhabdomyosarcoma cells (RD) (ATCC ...
Imaging Techniques Used in the Diagnosis of Pediatric Tumors
MB McCarville - Pediatric Malignancies: Pathology and Imaging, 2015
... In experienced hands US can safely be used to guide biopsy of a wide variety of tumors including rhabdomyosarcoma, non-rhabdomyosarcoma, soft-tissue sarcomas, neuroblastoma, hepatoblastoma, peripheral pulmonary lesions, and even anterior mediastinal masses ...
Alternative Splicing of MEF2C Controls its Activity in Normal Myogenesis and Promotes Tumorigenicity in Rhabdomyosarcoma Cells
M Zhang, B Zhu, J Davie - Journal of Biological Chemistry, 2014
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Many cellular disruptions contribute to the progression of this pediatric cancer including aberrant alternative splicing. The MEF2 family of transcription factors regulates many developmental programs, including myogenesis. MEF2 gene transcripts are subject to alternate splicing to generate protein isoforms with divergent functions. We found that MEF2Cα1 was the ubiquitously expressed isoform which exhibited no myogenic activity and that MEF2Cα2, the muscle specific MEF2C isoform, was required for efficient differentiation. We showed that exon α in MEF2C was aberrantly alternatively spliced in RMS cells, with the ratio of α2/α1 highly downregulated in RMS cells compared with normal myoblasts. Compared with MEF2Cα2, MEF2Cα1 more strongly interacted with and recruited HDAC5 to myogenic gene promoters to repress muscle specific genes. Overexpression of the MEF2Cα2 isoform in RMS cells increased myogenic activity and promoted differentiation in RMS cells. We have also identified a serine protein kinase, SRPK3, which was downregulated in RMS cells and found that expression of SRPK3 promoted the splicing of the MEF2Cα2 isoform and induced differentiation. Restoration of either MEF2Cα2 or SPRK3 inhibited both proliferation and anchorage independent growth of RMS cells. Together, our findings indicate the alternative splicing of MEF2C plays an important role in normal myogenesis and RMS development. Improved understanding of alternative splicing events in RMS cells will potentially reveal novel therapeutic targets for RMS treatment.
Cyclodextrin- and Calixarene-based Polycationic Amphiphiles as Gene Delivery Systems: A Structure-Activity Relationship Study
L Gallego-Yerga, M Lomazzi, V Franceschi, F Sansone… - Org. Biomol. Chem., 2014
... Evaluation in epithelial COS-7 and human Rhabdomyosarcoma RD-4 cells evidenced the importance of having primary amino groups in the vector to warrant high levels of transfection, probably because of their buffering capacity. ...
Drug-induced Acute Kidney Injury in Children
LN Faught, MJE Greff, MJ Rieder, K Gideon - British Journal of Clinical Pharmacology, 2014
... Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group. J Pediatr Hematol Oncol. ...
Creating a Tenuous Balance: Siblings’ Experience of a Brother’s or Sister’s Childhood Cancer Diagnosis
KA Long, AL Marsland, A Wright, P Hinds - Journal of Pediatric Oncology Nursing, 2014
... A 12-year-old sibling explained: It was just this big word that she had: rhabdomyosarcoma. ... A 17-year-old sister of a child with rhabdomyosarcoma and optical glioma explained: I realize now that there's always something that could pop up. ...