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MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes
M Sachdeva, JK Mito, CL Lee, M Zhang, Z Li, RD Dodd… - The Journal of Clinical …, 2014
... in sarcoma cell lines A and B increased their migration (Supplemental Figure 2, A–C). Also, overexpression of miR-182 in human sarcoma cell lines derived from undifferentiated pleomorphic sarcomas (UPS) (STS-48 and STS-109) or pleomorphic rhabdomyosarcoma (STS-145 ...

Prognostic model for predicting overall survival in children and adolescents with rhabdomyosarcoma
L Yang, T Takimoto, J Fujimoto - BMC Cancer, 2014
Background The purpose of this study was to develop a prognostic model for the survival of pediatric patients with rhabdomyosarcoma (RMS) using parameters that are measured during routine clinical management. Methods Demographic and clinical variables were ...

Uremic Toxins Enhance Statin-Induced Cytotoxicity in Differentiated Human Rhabdomyosarcoma Cells
H Uchiyama, M Tsujimoto, T Shinmoto, H Ogino, T Oda… - Toxins, 2014
Abstract: The risk of myopathy and rhabdomyolysis is considerably increased in statin users with end-stage renal failure (ESRF). Uremic toxins, which accumulate in patients with ESRF, exert cytotoxic effects that are mediated by various mechanisms. Therefore, accumulation ...

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
EC van Dalen, MF Raphaël, HN Caron, LC Kremer - The Cochrane database of …, 2014
... MAIN RESULTS: We identified RCTs for seven types of tumour, acute lymphoblastic leukaemia (ALL) (three trials; 912 children), Wilms' tumour (one trial; 316 children), rhabdomyosarcoma and undifferentiated sarcoma (one trial; 413 children), Ewing's sarcoma (one trial; 94 ...

Cytopathology: SS06-1 A SMALL ROUND CELL LESION IN THE NECK OF AN 11-YEAR-OLD CHILD.
DK Das - Pathology, 2014
... Besides lymphomas, the other pediatric small round cell tumors (SRCT) of the neck can be a group of malignancies that include neuroblastoma, Ewing's sarcoma, embryonal rhabdomyosarcoma, and metastasis from retinoblastoma and small cell undifferentiated carcinoma. ...

Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature
A Kurisaki-Arakawa, Y Suehara, A Arakawa, T Takagi… - Diagnostic pathology, 2014
... Diagn Pathol 2013, 8:147. 16. Lin XY, Wang Y, Yu JH, Liu Y, Wang L, Li QC, Wang
EH: Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report.
Diagn Pathol 2013, 8:18. 17. Martorell M, Ortiz CM, Garcia ...

Rhabdoid Carcinoma of Anal Canal: Role of Electron Microscopy and Immunohistochemistry in Establishing Lineage
BB Shetuni, U Irtaza, J Melnyk, PM Chou, S Rao… - Ultrastructural Pathology, 2014
... An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: The children's oncology group experience. ... Myogenin is a specific marker for rhabdomyosarcoma: An immunohistochemical study in paraffin-embedded tissues. ...

High temperature hyperthermia treatment for canines exhibiting superficial tumors: A report of three cases
H Takagi, K Azuma, T Osaki, N Itoh, S Nakazumi… - Oncology Letters
... In case 1, an 18‑year‑old female Papillon presented with a right forelimb rhabdomyosarcoma. ... 1A). Surgical excision of the tumor had been performed twice previously, however, the tumor had recurred. Histological analysis revealed that the tumor was a rhabdomyosarcoma. ...

Embryonal rhabdomyosarcoma of the paranasal sinuses: a case report and review of literature
PX Wu, YF Liang, JC Zeng, JB Ruan, DP Kang, C Chen… - Int J Clin Exp Med, 2014
Abstract: Embryonal rhabdomyosarcoma (ERMS) is a rare malignancy with a poor outcome. In this article, we describe a case of ERMS in the paranasal sinuses from a 60-year-old patient. ERMS derived from the paranasal sinuses is extremely rare. The diagnosis of ...

Application of immunohistochemistry in the diagnosis of small round blue-cell tumors of soft tissue.
Q Li, W Cui, G Abulajiang, Y Ma, X Liu, W Zhang, X Li - Clinical laboratory, 2014
... BACKGROUND: Small round blue-cell tumors (SRBCTs) of soft tissue, which mainly include rhabdomyosarcoma (RMS), synovial sarcoma (SS), and Ewing's sarcoma/peripheral primitive neuroectodermal tumors (EWS/ pPNETs), are malignancies with overlapping ...

Thyroid Abnormalities in Survivors of Childhood Cancer
AA Çağlar, A Oğuz, FG Pınarlı, C Karadeniz, A Okur… - J Clin Res Pediatr …, 2014
... The diagnoses of patients were lymphoma, leukemia, brain tumor, rhabdomyosarcoma and nasopharyngeal carcinoma (NPC). ... p-value significant when <0.05 HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, RMS: rhabdomyosarcoma, NPC: nasopharyngeal carcinoma ...

Tumor pathology of the orbit
F Héran, O Bergès, J Blustajn, M Boucenna… - … and Interventional Imaging, 2014
... Urgent imaging is needed as it may reflect a rhabdomyosarcoma, which is the commonest childhood mesenchymal tumor, orbital sites of which are usually embryonic tumors. ... Transferred to a specialist center and biopsied on the same day: rhabdomyosarcoma. ...

Head and Neck Pathology: Poster#182 PAEDIATRIC PARAMENIGEAL RHABDOMYOSARCOMA: A CASE REPORT - MULTIMODAL TREATMENT.
G Buname, R Byaruhanga, E Kakande, J Namwagala… - Pathology-Journal of the …, 2014
Abstract Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood,
representing 5% of all childhood cancers. We are reporting an interesting case of
parameningeal rhabdomyosarcoma in a child who underwent multimodal treatment. A 7- ...

Adaptive radiation therapy for pediatric head and neck malignancies: Dosimetric implications
S Laskar, P Pandit, S Mallik, P Tike, S Chaudhari… - Practical Radiation …, 2014
... Results. Five children had nasopharynx carcinoma, whereas the other 5 had
embryonal rhabdomyosarcoma. ... For patients with rhabdomyosarcoma, the CTV
included the gross prechemotherapy volume with a 1.5-cm margin. ...

Successfully managed case of rhabdomyosarcoma of bladder and prostate with poor response to intensive chemotherapy and obstructive uropathy
A Sinha, A Sabharwal, NH Choudhary, N Vasdev…
Abstract. Rhabdomyosarcoma () is the commonest soft tissue sarcoma in children. Of these bladder-prostate (-) is RMS BP RMS one of the most common primary sites. Treatment of these has recently revolved predominantly around chemotherapy with adjunct ...

PRIMARY CONJUNCTIVAL RHABDOMYOSARCOMA SUCCESSFULLY TREATED WITH SURGERY AND CHEMOTHERAPY
H YE, H YE, Y DING, YI DU, H YANG
Purpose: To report the outcome of a case of primary conjunctival rhabdomyosarcoma treated by surgical excision combined with chemotherapy Case report: A 4-year-old boy presented with a visible recurrence of conjunctival mass in the left eye. The orbital magnetic resonance ...

Bone and Soft Tissue Pathology: Poster#026 PAEDIATRIC SOFT TISSUE SARCOMAS IN A LOW RESOURCE SETTING: GRADE AND STAGE AT PRESENTATION ARE POOR PROGNOSTIC CHARACTERISTICS.
K Seki, M Kawata, T Miura
... Results: Ninety cases were seen with an almost equal male to female ratio and age range from 5 months to 14 years. The mean age was 7.45 (SD =3.97) years and the peak age group was 5–9 years. Rhabdomyosarcoma was the most common histological type (71.1%). ...

Mind the gap: extent of use of diffusion-weighted MRI in children with rhabdomyosarcoma
G Norman, D Fayter, K Lewis-Light, K McHugh… - Pediatric Radiology, 2014
Sir, We undertook a systematic review of the use of advanced functional imaging in the management of rhabdomyosarcoma in children and young people (age≤ 24 years)[1].
Studies of PET, PET-CT or diffusion-weighted MRI were eligible for inclusion if they ...

Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading
J Berkholz, W Kuzyniak, M Hoepfner, B Munz - Clinical & Experimental Metastasis, 2014
Abstract Skeletal and heart muscle-specific variant of the alpha subunit of nascent
polypeptide complex (skNAC) is exclusively present in striated muscle cells. During skeletal muscle cell differentiation, skNAC expression is strongly induced, suggesting that the ...

New insights into signalling-pathway alterations in rhabdomyosarcoma
B Zhu, JK Davie - British Journal of Cancer, 2014
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young
adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects ...

Congenital Eyelid Rhabdomyosarcoma.
YC Lee, YH Hsu, SH Yang, TL Huang - Ophthalmic Plastic & Reconstructive Surgery, 2014
Abstract: Rhabdomyosarcoma is the most common type of soft tissue sarcoma in children. The authors present a rare case of eyelid rhabdomyosarcoma in a newborn, who was found to have a reddish eyelid tumor in his OD. A mass with a clear margin, confined to the ...

Adult Alveolar Rhabdomyosarcoma of the Lacrimal Sac
JE Neffendorf, L Bagdonaite, HS Mudhar, AR Pearson - Orbit, 2014
Abstract Lacrimal sac tumours are rare, but must be considered in the diagnosis of patients presenting with masses in the medial canthal region. We report a single case of lacrimal sac rhabdomyosarcoma in a 31-year-old man. The patient self-presented to the eye ...

Contrast-enhanced MRI of the temporomandibular joint: findings in children without juvenile idiopathic arthritis
R Kottke, RK Saurenmann, MM Schneider, L Müller… - Acta Radiologica, 2014
... Diagnoses of these patients were: Langerhans cell histiocytosis with manifestation in skin, lymph nodes and relapse in skin and bone (sphenoid bone and right orbit), end of therapy 13 months prior to MRI; alveolar rhabdomyosarcoma of the left orbit, end of therapy 29 months ...

Child Abuse Masquerading as a Soft Tissue Sarcoma
L Strazzula, S Greenlaw, SO Vargas, L Belazarian - Pediatric Dermatology, 2014
... The large size and apparent rapid growth of the mass raised concern for a malignant process, and the initial differential diagnosis included infantile fibro- sarcoma, rhabdomyosarcoma, neuroblastoma, and dermatofibrosarcoma protuberans. ...

Bone mineral density after childhood cancer in 346 long-term adult survivors of childhood cancer
MAH den Hoed, BC Klap, ML Te Winkel, R Pieters… - Osteoporosis International, 2014
... Initial diagnoses of the survivors included acute lympho- blastic leukaemia (ALL), acute myeloid leukaemia (AML), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), brain tumour, sarcoma (rhabdomyosarcoma, Ewing sarcoma or osteosarcoma), renal tumour and ...

A Comprehensive Safety Evaluation of Trabectedin and Drug–Drug Interactions of Trabectedin-Based Combinations
C Leporini, M Patanè, F Saullo, P Rende, L Gallelli… - BioDrugs, 2014
... Finally, rhabdomyosarcoma typically affects children [3]. The primary therapy for the treatment of all patients with localized STS is surgical resection [2]. The standard surgical procedure includes a wide excision with negative margins, followed by radiation therapy for high-grade ...

Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review
NP Gannon, CA Conn, RA Vaughan - Molecular Nutrition & Food Research, 2014
... metabolic reprogramming through down-regulation of fatty acid biosynthesis. Interestingly, in human rhabdomyosarcoma cells, our lab has demonstrated that combination EPA/DHA can increase GLUT4 RNA and PGC-1α RNA and protein to stimulate glycolytic ...