Dr. David Langenau
His research focus is to uncover the mechanisms driving progression and relapse in pediatric tumors, including rhabdomyosarcoma. Using novel, transgenic zebrafish models of pediatric sarcoma and leukemia that mimic human malignancy, his group has undertaken studies to discover novel therapies by addition of drugs to the water and imaging tumor growth in live zebrafish. Moreover, they have utilized detailed imaging studies to visualize tumor cells in live animals and assess how cellular heterogeneity drives continued tumor growth. Capitalizing on insights gained from zebrafish models of cancer, the Langenau group is now extending findings to human T-cell acute lymphoblastic leukemia and rhabdomyosarcoma.
Dr. Langenau’s talk is centered on using the attributes of zebrafish to discover novel therapies and drug pathways that could be exploited in emerging treatments in patients.