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Dr. Frederic Barr

Dr. Frederic BarrDr. Barr is a Senior Investigator and Deputy Chief of the Laboratory of Pathology at the National Cancer Institute in Bethesda, MD. Dr. Barr received his undergraduate education at Williams College, and then attended Washington University School of Medicine, where he obtained his M.D. and Ph.D. degrees. Subsequently, he received residency training in anatomic pathology at the Hospital of the University of Pennsylvania and postdoctoral training in cancer genetics at the Division of Human Genetics and Molecular Biology at the Children’s Hospital of Philadelphia. Before coming to the National Cancer Institute, Dr. Barr was a faculty member in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine. His current research program focuses on the molecular genetics and clinical significance of recurrent chromosomal alterations in rhabdomyosarcoma. In addition to his research activities, Dr. Barr serves on the Steering Committee of the Soft Tissue Sarcoma Committee of the Children’s Oncology Group and is an Associate Editor for the Journal of Molecular Diagnostics.

This webinar describes the molecular characteristics of recurrent gene fusions in sarcomas with emphasis on the PAX3-FOXO1 and PAX7-FOXO1 gene fusions in rhabdomyosarcoma. The talk will next describe the strategies used for detection of these gene fusions in clinical material. Finally, the webinar will explore the clinical utility of these gene fusions in cancer diagnosis and management.