“The epidemiology of rhabdomyosarcoma: attempting to identify the different susceptibility factors”
View the Focus On Rhabdo Webinar that was recorded on August 17th at 2PM Eastern with Dr. Philip Lupo. Please log onto our website to view the video.
While several investigators are interested in characterizing the genetic makeup of rhabdomyosarcoma tumors and in improving treatment outcomes among children diagnosed with rhabdomyosarcoma, less work has been done in terms of understanding susceptibility to this important malignancy. The goal of epidemiology is not to simply describe the distribution of diseases, but also to identify susceptibility factors for disease, which will ultimately aid in prevention efforts. The purpose of this webinar is to briefly review epidemiologic methods for evaluating susceptibility factors, outline what is currently known in terms of the epidemiology of rhabdomyosarcoma, and discuss future directions in epidemiologic studies of rhabdomyosarcoma.
Dr. Philip Lupo is a molecular epidemiologist and an Assistant Professor in the Section of Hematology-Oncology of the Department of Pediatrics at Baylor College of Medicine. He is also a member of the epiCenter of the Texas Children’s Cancer Center. He is currently collaborating with other researchers and clinicians in the Children’s Oncology Group (COG) to build a research program in the epidemiology of rhabdomyosarcoma. Dr. Lupo is also an active collaborator with the Centers for Disease Control and Prevention-funded National Birth Defects Prevention Study (NBDPS) and is part of a multidisciplinary team of experts assessing the intersection of childhood cancer and birth defects. The ultimate goal of Dr. Lupo’s research is to discover factors that can be used in childhood cancer prevention efforts and targeted interventions to limit the adverse consequences of childhood cancer treatment.
Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group.
Lupo PJ, Danysh HE, Skapek SX, Hawkins DS, Spector LG, Zhou R, Okcu MF, Papworth K, Erhardt EB, Grufferman S., Cancer Causes Control. 2014 May 16. [Epub ahead of print] PMID: 24831857
Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group.
Lupo PJ, Zhou R, Skapek SX, Hawkins DS, Spector LG, Scheurer ME, Fatih Okcu M, Melin B, Papworth K, Erhardt EB, Grufferman S., Int J Cancer. 2014 Jan 15;134(2):431-6. doi: 10.1002/ijc.28363. Epub 2013 Aug 1. PMID: 23824786
Maternal-fetal metabolic gene-gene interactions and risk of neural tube defects.
Lupo PJ, Mitchell LE, Canfield MA, Shaw GM, Olshan AF, Finnell RH, Zhu H; National Birth Defects Prevention Study., Mol Genet Metab. 2014 Jan;111(1):46-51. doi: 10.1016/j.ymgme.2013.11.004. Epub 2013 Nov 18. PMID: 24332798