This month’s issue of Nature Reviews|Cancer (March 2014) hightlights an advancement in the understanding of alveolar rhabdomyosarcoma. Drs. Charles Keller,Ken Kikuchi and colleagues “generated an aRMS knockin mouse model that expresses the common fusion gene paired box 3 (Pax3)-forkhead box O1A (Foxo1a) under the regulation of the normal Pax3 promoter. The authors also expressed an enhanced yellow fluorescent protein (eYFP) as a second cistron in the Pax3-Foxo1a mRNA…”
“…In samples that lack fusion genes, the authors found mutations in genes that were previously known to be involved in RMS, such as the RAS genes and fibroblast growth factor receptor 4 (FGFR4), as well as mutations in F-box and WD repeat domain containing 7 (FBXW7) and BCL6 co-repressor (BCOR), which are two genes that were not previously known to be mutated in RMS.”
The article, written by Nicola McCarthy and is available by subscription on the Nature.com website.