Focus On Rhabdo
March 5, 2017
Dr. Zoe Walters – Institute of Cancer Research
Epigenetics describes the study and role of specific markers on DNA and associated histone proteins. The work that Zoë has undertaken within Janet’s team at the ICR and during her CWCUK fellowship has focused on the role of proteins that alter the epigenetic status of rhabdomyosarcomas. Histone modifying enzymes regulate intracellular transcriptional networks to tightly control gene expression and DNA repair, and ultimately control cell proliferation and differentiation. Zoë’s presentation will outline the work she has been doing on the histone modifying protein complex Polycomb Recessive Complex 2 (PRC2), how this complex is aberrantly expressed in rhabdomyosarcomas and how targeting this protein complex might be exploited for therapeutic intervention in this and other soft tissue sarcomas.
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