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Radiation therapy may increase metastatic potential in alveolar rhabdomyosarcoma
GM Woods, K Bondra, C Chronowski, J Leasure… – Pediatric Blood & Cancer, 2015
Background We previously determined that radiation could be safely administered using a mouse-flank in vivo model to both alveolar (Rh30) and embryonal (Rh18) rhabdomyosarcoma xenografts. Mice from both tumor lines in this experiment developed …

Extratesticular masses in children: taking ultrasound beyond paratesticular rhabdomyosarcoma
A Annam, MM Munden, AR Mehollin-Ray, D Schady… – Pediatric Radiology, 2015
Abstract Extratesticular cystic and solid scrotal masses are commonly encountered in pediatrics. The most common extratesticular malignancy is paratesticular rhabdomyosarcoma. The remainder of the common pathologies encountered-appendage …

Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomised, open-label, phase 2 study
A Kawai, N Araki, H Sugiura, T Ueda, T Yonemoto… – The Lancet Oncology, 2015
… Eligible patients were pathologically diagnosed at the study site with a translocation-related sarcoma: myxoid round-cell liposarcoma, synovial sarcoma, alveolar rhabdomyosarcoma, extraskeletal Ewing sarcoma/primitive neuroectodermal tumour, dermatofibrosarcoma …

Screening and surveillance CT abdomen/pelvis for metastases in patients with soft-tissue sarcoma of the extremity
MJ Thompson, J Ross, G Domson, W Foster – Bone and Joint Research, 2015
… Isolated abdominal metastases were observed in one each of clear cell sarcoma, pleomorphic sarcoma, myxoid liposarcoma, and rhabdomyosarcoma. Three of 24 patients with liposarcoma of any type developed metastases. …

Dysregulation of microRNA biogenesis and gene silencing in cancer
A Hata, J Lieberman – Science Signaling, 2015
… 3, A and B). Furthermore, both somatic and germline DICER1 mutations have been associated with human cancer syndromes, including familial pleuropulmonary blastoma, pituitary blastoma, and embryonal rhabdomyosarcoma (104–106) (Fig. 3B). …

The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells
Y Wang, A Han, E Chen, RK Singh, CO Chichester… – International Journal of …, 2015
Page 1. INTERNATIONAL JOURNAL OF ONCOLOGY Abstract. Cranberry flavonoids (flavonols and flavan-3-ols), in addition to their antioxidant properties, have been shown to possess potential in vitro activity against several cancers. …

Clonality and Evolutionary History of Rhabdomyosarcoma
L Chen, JF Shern, JS Wei, ME Yohe, YK Song, L Hurd… – PLoS genetics, 2015
Abstract To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44 tumor- …

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation.
N Casini, IM Forte, G Mastrogiovanni, F Pentimalli… – Oncotarget, 2015
Recent data suggest that SRC family kinases (SFKs) could represent potential therapeutic targets for rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. Here, we assessed the effect of a recently developed selective SFK inhibitor (a pyrazolo [3 …

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.
L Chen, B Xu, L Liu, C Liu, Y Luo, X Chen, M Barzegar… – Oncotarget, 2015
… Here we show that rapamycin inhibits the basal and IGF-1 stimulated adhesion of
tumor cells derived from human rhabdomyosarcoma (Rh30), Ewing sarcoma (Rh1),
colon carcinoma (HT29) and cervical adenocarcinoma (HeLa). …

Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
K Miyazaki, NP Jerome, DJ Collins, MR Orton… – European Radiology, 2015
… grade glioma 5 F/9 Glioblastoma multiforme 6 M/8 Glioblastoma multiforme 7 M/15 Anaplastic astrocytoma 8 M/11 Astrocytoma Extracranial tumour 9 M/7 Ganglioneuroblastoma 10 M/13 Spindle cell sarcoma 11 F/12 Ganglioneuroblastoma 12 M/14 Rhabdomyosarcoma 13 M …

Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq
SV Bratman, AM Newman, AA Alizadeh, M Diehn – Expert Review of Molecular …, 2015
… Radiother Oncol 2012;102(3):335-42 CIT0018. Ferrari A, Miceli R, Meazza C, et al. Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma.

The Case for Primary Salivary Rhabdomyosarcoma
M Geltzeiler, G Li, J Abra
ham, C Keller – Name: Frontiers in Oncology, 2015
Abstract Rhabdomyosarcomas of the parotid and submandibular glands have the histological appearance of a skeletal muscle tumor yet can be found in tissue with no striated muscular elements. We examine the potential cell-oforigin for rhabdomyosarcoma …

Urological problems in neonates and children
G Subramanian, A Shirsalkar, J Pitts – InnovAiT: Education and inspiration for general …, 2015
… Rhabdomyosarcoma. Rhabdomyosarcoma (RMS) is the most common sarcoma in children. … RMS. Reproduced from Cost NG, Routh JC, Kieran K. Genitourinary Rhabdomyosarcoma. Pediatric Urology Book, with permission. …