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The PAX3-FOXO1 Fusion Protein Present in Rhabdomyosarcoma Interferes with Normal FOXO Activity and the TGF-β Pathway
M Schmitt-Ney, G Camussi – PloS one, 2015
PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alveolar subtype of Rhabdomyosarcoma, a pediatric sarcoma with myogenic phenotype. PAX3-FOXO1 is an aberrant but functional transcription factor. It …

CDK4 amplification reduces sensitivity to CDK4/6 inhibition in fusion-positive rhabdomyosarcoma
ME Olanich, W Sun, SM Hewitt, Z Abdullaev, S Pack… – Clinical Cancer Research, 2015
Purpose: Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and includes a PAX3-or PAX7-FOXO1 fusion-positive subtype. Amplification of chromosomal region 12q13-q14, which contains the CDK4 proto-oncogene, was identified in an …

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells
S Honisch, W Yu, G Liu, I Alesutan, ST Towhid… – Oncotarget, 2015
Chorein encoded by VPS13A (vacuolar protein sorting-associated protein 13A) is defective in chorea-acanthocytosis. Chorein fosters neuronal cell survival, cortical actin polymerization and cell stiffness. In view of its anti-apoptotic effect in neurons, we explored whether chorein is …

Bilateral internal hemipelvectomy for osteosarcoma in a pediatric patient previously treated for rhabdomyosarcoma
I Fernandez-Pineda, MB McCarville, RC Brennan… – … & Traumatology: Surgery & …, 2015
Abstract The surgical treatment of malignant bone tumors involving the pelvis represents a great challenge in terms of local control. Internal hemipelvectomy is a major surgical procedure that involves the resection of the entire hemipelvis or of a portion of the …

Family history of cancer and childhood rhabdomyosarcoma:a report from the Children’s Oncology Group and the UtahPopulati on Database
PJ Lupo, HE Danysh, SE Plon, K Curtin, D Malkin… – Cancer Medicine, 2015
Abstract Relatively little is known about the epidemiology and factors underlying susceptibility to childhood rhabdomyosarcoma (RMS). To better characterize genetic susceptibility to childhood RMS, we evaluated the role of family history of cancer using …

Primary sclerosing rhabdomyosarcoma of the scalp and skull: report of a case and review of literature
Q Chen, W Lu, B Li – Int J Clin Exp Pathol, 2015
Abstract: We present a case of sclerosingrhabdomyosarcoma of the skull in a young male. This is a rare tumor that immunophenotypically shows rhabdomyoid differentiation. The lesion had a moderately aggressive course and the patient died at 19 months after …

Initial testing (stage 1) of the tubulin binding agent nanoparticle albumin-bound (nab) paclitaxel (Abraxane®) by the Pediatric Preclinical Testing Program (PPTP)
PJ Houghton, RT Kurmasheva, EA Kolb, R Gorlick… – Pediatric Blood & Cancer, 2015
… Conclusions. The high level of activity observed against the rhabdomyosarcoma and Ewing sarcoma PPTP preclinical models makes nab-paclitaxel an interesting agent to consider for pediatric evaluation. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. INTRODUCTION. …

Use of patient registries and administrative datasets for the study of pediatric cancer
HE Rice, BR Englum, BC Gulack, OO Adibe, ET Tracy… – Pediatric Blood & Cancer, 2015
… However, as these groups’ data is based on American Joint Commission on Cancer (AJCC) staging, their value is limited for pediatric cancers that use other staging systems, such as neuroblastoma and rhabdomyosarcoma. …