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Inhibition of metastasis of rhabdomyosarcoma by a novel neutralizing antibody to CXCR4
K Kashima, M Watanabe, Y Sato, J Hata, N Ishii, Y Aoki - Cancer Science, 2014
Summary Rhabdomyosarcoma is the most common soft tissue sarcoma affecting children,
and the overall cure rate of children with metastatic disease remains below 30%. The CXC
chemokine receptor-4 (CXCR4)/stromal-derived factor-1 (SDF1) axis has been implicated ...

Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun Damaged Skin: A Case Report.
JJ Li, D Forstner, C Henderson - The American Journal of Dermatopathology, 2014
Abstract: Rhabdomyosarcoma (RMS) is a malignant soft tissue tumor with skeletal muscle
differentiation that can rarely present as a primary cutaneous tumor. There are 3 main
subtypes of RMS: embryonal, alveolar, and pleomorphic. Primary cutaneous pleomorphic ...

Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma
C Urla, S Armeanu-Ebinger, J Fuchs, G Seitz - Surgical Endoscopy, 2014
Background Surgery for rhabdomyosarcoma is challenging due to a lack of clear delineation
between tumor and surrounding tissue. Mutilating surgery can be necessary in difficult tumor localizations. Therefore, novel diagnostic and therapeutic modalities are required. The ...

Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry
A Almazán‐Moga, J Roma, C Molist, I Vidal, L Jubierre… - Cytometry Part A, 2014
Abstract Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in
children. Circulating tumor cells in peripheral blood or disseminated to bone marrow, a
concept commonly referred to as minimal residual disease (MRD), are thought to be key to ...

Clinical features, instrumental diagnostics and surgical treatment of orbital rhabdomyosarcoma in children
S SAAKYAN, A AMIRYAN, O IVANOVA, R TATSKOV - Acta Ophthalmologica, 2014
Results In all case the progressive proptoses with vision decreasing in short period of time were noticed (from 2 weeks to 4 month). CT scan demonstrated a solid mass with accurate margins, localized in different part of the orbit (mainly under the upper roof – in 6 cases) ...

Incidence and Survival of Pediatric Soft Tissue Sarcomas: Comparison between Adults and children.
SM Lim, CJ Yoo, JW Han, YJ Cho, SH Kim, JB Ahn… - Cancer research and …, 2014
... Purpose: Pediatric-type sarcomas such as rhabdomyosarcoma (RMS), Ewing sarcoma (EWS),
primitive neuroectodermal tumor (PNET), and desmoplastic small round-cell tumor (DSRCT)
are rare in adults, with limited studies on their prognosis and optimal treatment strategies. ...

PDGF receptors in tumor biology: prognostic and predictive potential
J Paulsson, M Ehnman, A Östman - Future Oncology, 2014
... PDGFR signaling has also been implied as drivers of the growth in malignant cells of other types of sarcoma including rhabdomyosarcoma and Ewing's sarcoma. ... Studies in a genetic mouse model of rhabdomyosarcoma have linked PDGFRα to disease progression [33]. ...

Immunotherapy in pediatric malignancies: current status and future perspectives
CM Capitini, M Otto, KB DeSantes, PM Sondel - Future Oncology, 2014
... The mAb bevacizumab inhibits VEGF, a signaling pathway presumed to be critical for
supply to solid tumors, and has shown activity as a single agent in some studies of
relapsed astrocytoma [7,8], neuroblastoma and rhabdomyosarcoma [8], but not in ...

Primary Intraventricular Central Nervous System Rhabdomyosarcoma
KI Rao, DM Malicki, JR Crawford - Pediatric Neurology, 2014
This is a PDF file of an unedited manuscript that has been accepted for publication. As a
service to our customers we are providing this early version of the manuscript. The
manuscript will undergo copyediting, typesetting, and review of the resulting proof before it ...

Lack of treatment-related mortality definitions in clinical trials of children, adolescents and young adults with lymphomas, solid tumors and brain tumors: a systematic review
TH Tran, M Lee, S Alexander, P Gibson, U Bartels… - BMC Cancer, 2014
... Only one randomized trial of rhabdomyosarcoma provided a definition of early death.
multicenter randomized trial from the International Rhabdomyosarcoma Study Group (IRSG)
defined early death as any death occurring within 6 weeks of treatment initiation [6]. ...

Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary
R Sunku, R Duggal, FD Patel, B Rai, R Srinivasan…
> Abstract We report this first case of synchronous cervical rhabdomyosarcoma and Sertoli-
Leydig cell tumor (SLCT) of ovary with congenital absence of unilateral ovary and fallopian tube in a 16-year-old female patient. A review of the English-language literature identified ...

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
F Ewald, D Nörz, A Grottke, BT Hofmann, B Nashan… - Investigational New Drugs, 2014
... The same agents were used in a recent study by Renshaw et al. on rhabdomyosarcoma cell
lines, reporting strong synergistic effects [39] due to suppression of an ERK/mTOR/AKT feedback loop which restores tumor viability as long as only one respective pathway is blocked. ...