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A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
S Kohsaka, N Shukla, N Ameur, T Ito, CKY Ng, L Wang… - Nature Genetics, 2014
Rhabdomyosarcoma, a cancer of skeletal muscle lineage, is the most common soft-tissue
sarcoma in children 1. Major subtypes of rhabdomyosarcoma include alveolar (ARMS) and
embryonal (ERMS) tumors 2, 3. Whereas ARMS tumors typically contain translocations ...

Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA
U Heinicke, S Fulda - Cancer Letters, 2014
Abstract Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood
with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we
identify a novel synthetic lethal interaction between the histone deacetylase inhibitor ( ...

Hyper-Activation of Notch3 Amplifies the Proliferative Potential of Rhabdomyosarcoma Cells
M De Salvo, L Raimondi, S Vella, L Adesso… - PLOS ONE, 2014
Abstract Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma
that includes two major histopathological subtypes: embryonal and alveolar. The majority of
alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst ...

Alveolar rhabdomyosarcoma in children with histomorphological review
SK Nema, A Singh, H Bhasker, P Bhambani… - International Journal of …, 2014
Abstract Rhabdomyosarcomas (RMS) are aggressive malignant neoplasm of mesenchymal
origin, related to skeletal muscle lineage. These are the most common soft tissue tumors in
children. The diagnosis is made by microscopic analysis and ancillary techniques like ...

FCP 6 : Rhabdomyosarcoma mistaken for cellulitis occurred on the face
YA No, SJ Seo - 프로그램북 (구 초록집), 2014
Rhabdomyosarcoma is a rare malignant soft tissue neoplasm with skeletal muscle
differentiation. Cutaneous rhabdomyosarcoma is exceedingly rare, and in most cases, it
represents metastatic disease or the dermal involvement by a tumor arising on the ...

Therapeutic In-Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case report, Hypothesis, and Clinical Trial
AM Salazar, RB Erlich, A Mark, N Bhardwaj… - Cancer Immunology …, 2014
... lysine-carboxymethylcellulose (poly-ICLC, Hiltonol®). We report the first treated
patient, a young man with an exceptionally advanced facial embryonal
rhabdomyosarcoma with extension to brain. The patient showed tumor ...

Round cell sarcomas – Biologically important refinements in subclassification
A Mariño-Enríquez, CDM Fletcher - The International Journal of Biochemistry & Cell …, 2014
... clinical course. Specific subtypes of round cell sarcoma, like Ewing sarcoma or
rhabdomyosarcoma, respond to well-defined therapeutic regimens so that proper
classification is crucial for appropriate patient management. A ...

Pituitary metastasis of rhabdomyosarcoma: a case report and review of the literature
Essadi Ismail, Lalya Issam and Mansouri Hamid, Jrnl Med Case Rpts, May 2014
The pituitary gland is an uncommon site for metastases, in particular from rhabdomyosarcoma. Some authors have reported a recent increase in the incidence of metastases at infrequent sites, such as brain or bone, probably due to the expanded treatment options and the resulting improved survival. Treatment options are limited, but must be discussed and adapted to the patient profile.