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Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma
EY Chen, MT DeRan, MS Ignatius, KB Grandinetti… – Proceedings of the National …, 2014
Abstract Embryonal rhabdomyosarcoma (ERMS) is a common pediatric malignancy of
muscle, with relapse being the major clinical challenge. Self-renewing tumor-propagating
cells (TPCs) drive cancer relapse and are confined to a molecularly definable subset of …

Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program
H Carol, JM Maris, MH Kang, CP Reynolds, EA Kolb… – Pediatric Blood & Cancer, 2014
… Aberrant Notch signaling has been implicated in several pediatric malignancies in addition to
the hallmark T-lineage ALL [1], including medulloblastoma [6], glioblastoma [7],
rhabdomyosarcoma [8], Ewing sarcoma [9], and particularly osteosarcoma [10-12]. …

Oral Rhabdomyosarcoma: A Case Report
D Parviz, K Saeideh – J Clin Exp Pathol, 2014
Abstract Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm of skeletal muscle
origin. The most common sites of occurrence are the head and neck, genitourinary tract, and
extremities. Although Rhabdomyosarcoma has a relative predominance for head and …

Biopsy-Proven Spontaneous Regression of a Rhabdomyomatous Mesenchymal Hamartoma
JM Mazza, E Linnell, HJ Votava, JH Wisoff… – Pediatric Dermatology, 2014
… Differential diagnoses of these lesions include fibrous hamartoma of infancy, benign Triton tumor
(a neuromuscular tumor), nevus lipomatosus superficialis, and cutaneous embryonal
rhabdomyosarcoma, but none of these lesions demonstrate the classic features described for …

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells
JJ Lin, CS Huang, J Yu, GS Liao, HC Lien, JT Hung… – Breast Cancer Research, 2014
Although breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little
is known about their tumor biology. Malignant phyllodes tumor contains heterologous stromal
elements, and can transform into rhabdomyosarcoma, liposarcoma and osteosarcoma. …

Sorafenib in advanced, heavily pretreated patients with soft tissue sarcomas
K Brämswig, F Ploner, A Martel, T Bauernhofer… – Anti-Cancer Drugs, 2014
… Two patients had angiosarcoma, synovial sarcoma, or undiffer- entiated pleomorphic sarcoma
with giant cells; one case each had clear cell sarcoma of soft tissue, differentiated liposarcoma,
embryonal rhabdomyosarcoma, extraskeletal Ewing tumor, hemangiopericytoma …

CT and MRI findings in cardiac tumoral and pseudotumoral lesions
JCG Beuth, IS Lite, AR Orodea
… Angiosarcoma and rhabdomyosarcoma are the commonest malignancies in aduthood and
childhood respectibly. CLINICAL MANIFESTATIONS … Angiosarcoma Other Sarcomas •
Rhabdomyosarcoma • Fibrosarcoma • Neurogenic sarcoma • Myxosarcoma Page 4. Page 4 of …