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A Rare Case of Prostatic Extra Gonadal Germ Cell Tumor in a Young Adult: Review of the Literature
S Sydris, P Aftimos, A Georgala, N Sirtaine, A Awada - J Clin Diagn Res, 2014
... A biopsy revealed an embryonal rhabdomyosarcoma of the prostate and the patient was treated with pre-operative chemotherapy according to the pediatric protocol IVAD (Ifosfamide -Actinomycin - Doxorubicin – Vincristine) followed by prostatectomy and cystectomy. ...

PO-0164 Paediatric Soft Tissue Sarcoma: A Ten Year Review
M Pinheiro, AM Ferreira, A Pinto - Archives of Disease in Childhood, 2014
... Abstract. Background and aims Paediatric soft tissue sarcomas are rare tumours that account for about 7% of all childhood cancers. 50–60% of these are rhabdomyosarcoma (RMS), while the remainder are non rhabdomyosarcoma soft tissue sarcomas (NRSTS). ...

Management of Recurrent or Metastatic Retroperitoneal Soft-Tissue Sarcomas
D Damianov, Y Asenov, P Kurtev, N Penkov, B Korukov… - Chirurgia (Bucur), 2014
... Leiomyosarcoma 4 39 12 Histiocytoma 3 13 6 Rhabdomyosarcoma 2 12 No data Fibromyxosarcoma 2 36 26 Myofibrosarcoma 1 24 3 ... Fibrosarcoma 8 4 4.5 Histiocytoma 6 3 3.4 Rhabdomyosarcoma 4 2 2.2 Fibromyxosarcoma 4 2 2.2 Myofibrosarcoma 1 1 1.1 ...

Roles of integrin-linked kinase in cell signaling and its perspectives as a therapeutic target
CF Yen, HS Wang, CL Lee, SK Liao - Gynecology and Minimally Invasive Therapy, 2014
... One example is that ILK acts as an oncogene in the highly aggressive pediatric alveolar rhabdomyosarcoma, but contradictorily as a tumor suppressor in the embryonal rhabdomyosarcoma. The mechanism by which this occurred ...

Acute kidney injury due to bilateral ureteral obstruction in children
D Bianchi, G Vespasiani, P Bove - World J Nephrol, 2014
... One case has been described of a 4-year-old girl presenting with an embryonal rhabdomyosarcoma, botryoid variant, arising within the left ureter[ 85 ]. ... The most represented tumor was neuroblastoma, followed by immature teratoma and rhabdomyosarcoma. ...

Reverse Phase Protein Arrays: Mapping the Path Towards Personalized Medicine
RI Gallagher, V Espina - Molecular Diagnosis & Therapy, 2014
... 75]. To address the lack of response to chemotherapy in children with rhabdomyosarcoma, Petricoin et al. [21 ... inhibitor. CCI-779 significantly reduced tumor growth in the mouse xenograft model of rhabdomyosarcoma [21]. Thus ...

MRI in Pediatric Oncology, Abdominal Tumors: Diffusion
JL de Oliveira Schiavon, GG Pioner, HM Lederman - Current Radiology Reports, 2014
... As well as neuroblastoma, Ewing's sarcoma (EWS), peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, and hepatoblastoma [ 13 ], nephroblastoma tumors are characterized by high cellularity, small, round ...

Regulation of Skeletal Muscle Development and Disease by microRNAs
N Liu, R Bassel-Duby - Vertebrate Myogenesis, 2015
... E, Pappo AS, Link MP, Anderson JR, Parham DM, Qualman SJ, Wharam MD, Donaldson SS, Maurer HM, Meyer WH, Baker KS, Paidas CN, Crist WM (2003) Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma–a report from ...

PO-0166 The Langerhans Cell Histiocytosis In Children: Study Of 11 Cases
L Sfaihi, Y Belfitouri, F Kamoun, I Maaloul, S Alibi… - Archives of Disease in …, 2014
... Background and aims Paediatric soft tissue sarcomas are rare tumours that account for about 7% of all childhood cancers. 50–60% of these are rhabdomyosarcoma (RMS), while the remainder are non rhabdomyosarcoma soft tissue sarcomas (NRSTS). ...

ErbB Receptors as Prognostic and Therapeutic Drug Targets in Bone and Soft Tissue Sarcomas
H Wang, Q Yang, Z Fu, D Zuo, Y Hua, Z Cai - Cancer Investigation, 2014
... epithelioid areas (82). ErbB receptors in Rhabdomyosarcoma Rhabdomyosarcoma (RMS) is the most common soft-tissue malignant tumor of childhood, which is derived from primitive skeletal muscle tissue (83). RMS is composed ...

Health disparities are important determinants of outcome for children with solid tumor malignancies
MT Austin, H Nguyen, JM Eberth, Y Chang, A Heczey… - Journal of Pediatric Surgery, 2014
... solid tumor malignancies. Baker and colleagues [7] conducted a retrospective cohort analysis of patients treated on Intergroup Rhabdomyosarcoma Study Group (IRSG) protocols between 1984 and 1997. They found that although ...

Signaling pathway profiling by reverse-phase protein array for personalized cancer medicine
M Masuda, T Yamada - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2014
... assessed the activation status of the Akt/mTOR pathway in 59 LCM tumor specimens from pediatric rhabdomyosarcoma patients in clinical trials designed to evaluate a series of combination regimens including VAC (vincristine, actinomycin D and cyclophosphamide), VAI (VA ...

Phase I clinical trials test new therapies for kids’ cancers
L Hilton - 2014
... According to the American Cancer Society, the most common types of cancer diagnosed in children and adolescents are leukemia; brain and central nervous system tumors; lymphoma; rhabdomyosarcoma; neuroblastoma; Wilms tumor; retinoblastoma; and bone cancer. 5. ...

Immune-based therapies for childhood cancer
CL Mackall, MS Merchant, TJ Fry - Nature Reviews Clinical Oncology, 2014
After decades of research, immunotherapies for cancer are demonstrating increasing success. These agents can amplify existent antitumour immunity or induce durable antitumour immune responses in a wide array of cancers. The spectrum of immunotherapeutics is broad, spanning monoclonal antibodies and their derivatives, tumour vaccines, and adoptive therapies using T cells and natural killer cells. Only a small number of immunotherapies have been tested in paediatric cancers, but impressive antitumour effects have already been observed. Mononclonal antibodies targeting GD2 that induce antibody-dependent cell-mediated cytotoxicity improve survival in high-risk neuroblastoma. Bi-specific monoclonal antibodies that simultaneously target CD19 and activate T cells can induce remission in acute B-cell lymphoblastic leukaemia (B-ALL) and adoptive immunotherapy using T cells genetically engineered to express chimeric antigen receptors targeting CD19 induce impressive responses in B-ALL. Efforts are underway to generate and test new immunotherapies in a wider array of paediatric cancers. Major challenges include a need to identify immunotherapy targets on the most lethal childhood cancers, to expand availability of technology-intense platforms, such as adoptive cell therapy, to optimize management of novel toxicities associated with this new class of cancer therapies and to determine how best to incorporate these therapies into standard treatment paradigms.

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
L Tan, J Wang, J Tanizaki, Z Huang, AR Aref, M Rusan… - Proceedings of the National …, 2014
... In humans the FGFR4 V550L gatekeeper mutation was detected in 9% (4/43) of embryonal rhabdomyosarcoma tumors (49), and the FGFR4 V550M mu- tation was detected in 13% (2/15) of neuroendocrine breast carcinomas (50).

Interactive Labeling of Toponome Data
S Oeltze-Jafra, F Pieper, R Hillert, B Preim, W Schubert
... phenotypes. We demonstrate our approach by toponome data of a rhabdomyosarcoma cell line and a prostate tissue section. ... 6. Application We demonstrate our approach by a rhabdomyosarcoma cell line and a prostate tissue section. Both ...

Chemotherapy for Childhood Orbital Tumors
JC Davis - Orbital Tumors, 2015
... In this chapter the chemotherapy used for the treatment of the following conditions will be discussed: (1) primary malignant orbital tumors such as rhabdomyosarcoma, lymphoma, and myeloid sarcoma; (2) malignancies that may metastasize to the orbit including neuroblastoma ...

Orbital Cancer Staging
PT Finger, B Haik - Orbital Tumors, 2015
... For example, in treatment of rhabdomyosarcoma, cancer and side-effect staging allowed orbital specialists to define best methods of diagnosis and treatment [ 10 , 11 ]. ... 2011;27(2):142.PubMed CrossRef. 10. Tsokos M, Webber BL, Parham DM, et al. Rhabdomyosarcoma. ...

Diagnosis and Management of Soft-tissue Masses
JL Mayerson, TJ Scharschmidt, VO Lewis, CD Morris - Journal of the American …, 2014
... Certain types of soft-tissue sarcoma have a predilection for certain age groups or anatomic locations. For example, rhabdomyosarcoma most commonly affects children, and synovial sarcoma most commonly affects young adults. Epithelioid sarcoma often affects the hand. ...