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We welcome Dr. Eleanor Chen at the University of Washington, Department of Pathology as a participating laboratory in Focus On Rhabdo Bio-Specimen Donation Initiative.

According to the UW-Medicine website, Dr. Chen’s main research interest is in understanding pathogenesis of cancer using zebrafish and mammalian experimental systems. Her current research focuses on dissecting cellular and molecular mechanisms underlying pediatric embryonal rhabdomyosarcoma, in particular the key events driving relapse and metastasis. Her laboratory utilizes high-throughput chemical genetic and genomic approaches to identify key driver events of embryonal rhabdomyosarcoma. In addition, by imaging cellular processes in our transgenic zebrafish tumor models, she seeks to dissect key cellular events leading to relapse and metastasis.

Her clinical interest is in bone and soft tissue pathology.

To donate bio-specimens to Dr. Chen’s laboratory, please check our our Bio-Specimen Initiative page.

Recent Publications:

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.
Chen EY, Deran MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54. doi: 10.1073/pnas.1317731111. Epub 2014 Mar 24.

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation.
Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM.
Cancer Cell. 2014 Mar 17;25(3):366-78. doi: 10.1016/j.ccr.2014.01.032. Epub 2014 Mar 6.

High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma.
Selvarajah S, Pyne S, Chen E, Sompallae R, Ligon AH, Nielsen GP, Dranoff G, Stack E, Loda M, Flavin R.
Clin Cancer Res. 2014 Mar 15;20(6):1521-30. doi: 10.1158/1078-0432.CCR-13-2090. Epub 2014 Feb 3.